FIGURE 5.
Syt2 deficiency does not affect other MC secretory mechanisms. Secreted products were measured in supernatants of BMMCs from Syt2+/+ and Syt2−/− mice incubated with anti-DNP IgE before and at different time points after addition of DNP-HSA. A, TNF-α before (open bars) and after (6 h, black bars) challenge (n = 5; color legend applies also to C and D). B, time course of IL-4 secretion (n = 3 per time point). C, PGD2 and D, LTC4 30 min after challenge (n = 4 for both). Secretion dependent on constitutive exocytosis or independent of exocytosis was not affected in Syt2−/− BMMCs. (Error bars represent S.E.)