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Conformational changes in the IYD active site to accommodate MIT and DIT. A, the surface characteristics of the active site of IYD for the IYD·MIT co-crystal crystal calculated using vacuum electrostatics in PyMOL (47). Blue indicates positive charge, and red indicates negative charge. B, alignment of active site structures of IYD bound with MIT (orange) and DIT (cyan) illustrates the minor conformational change required to accommodate the larger substrate.
