Table 1.
Assesment of cytotoxicity and haemolytic activity of partially fluorinated carbohydrate surfactants and their hydrocarbon analogues in B16F10 cell line.a
| Entry | Structure of tails | Cytotoxicity EC50 (μM) | Haemolytic activity EC50 (mM) |
|
|---|---|---|---|---|
| without serum | 20 % serum | |||
| Alkyl glucopyranosides | ||||
| α-13b | C14H29 | 53 | 2.5 | >3.3 (30%) |
| α-13c | C15H31 | 67 | >3.3 (20%) | >3.3 |
| α-13d | C16H33 | 70 | >3.3 (20%) | >3.3 |
| α-13e | C17H35 | 37 | >3.3 (25%) | >3.3 |
| α-13f | C18H37 | >250 | >3.3 | >3.3 |
| α-13g | C19H39 | >250 | >3.3 | >3.3 |
| β-13a | C7H15 | >250 | >3.3 | >3.3 |
| β-13bb | C14H29 | 41 | 1.7 | 2.5 |
| β-13cb | C15H31 | 38 | 0.8 | 2.5 |
| β-13db | C16H33 | 50 | >3.3 (30%) | >3.3 |
| β-13eb | C17H35 | 38 | 2.5 | >3.3 (5%) |
| β-13fb | C18H37 | 32 | >3.3 (10%) | >3.3 |
| β-13gb | C19H39 | 100 | >3.3 | >3.3 |
| (α+β)-13bc | C14H29 | 62 | 0.8 | 1.7 |
| (α+β)-13gd | C19H39 | >250 | >3.3 (5%) | >3.3 |
| Perfluoroalkyl glucopyranosides | ||||
| α-14d | (CH2)10C6F13 | 47 | >3.3 (5%) | >3.3 |
| α-14f | (CH2)10C8F17 | >250 | >3.3 | >3.3 |
| β-14a | (CH2)3C4F9 | >250 | >3.3 | >3.3 |
| β-14bb | (CH2)10C4F9 | 32 | >3.3 (10%) | >3.3 (10%) |
| β-14cb | (CH2)11C4F9 | 32 | 2.5 | >3.3 |
| β-14db | (CH2)10C6F13 | 52 | >3.3 (25%) | >3.3 |
| β-14eb | (CH2)11C6F13 | 30 | >3.3 | >3.3 |
| β-14fb | (CH2)10C8F17 | >250 | >3.3 | >3.3 |
| β-14gb | (CH2)11C8F17 | >250 | >3.3 | >3.3 |
| (α+β)-14ae | (CH2)3C4F9 | >250 | >3.3 | >3.3 |
| (α+β)-14gf | (CH2)11C8F17 | >250 | >3.3 | >3.3 |
| Alkyl galactopyranosides | ||||
| α-15c | C18H37 | >250 | >3.3 | >3.3 |
| β-15a | C7H15 | >250 | >3.3 | >3.3 |
| β-15b | C16H33 | >250 | >3.3 (40%) | >3.3 |
| β-15c | C18H37 | >250 | >3.3 (20%) | >3.3 |
| Perfluoroalkyl galactopyranosides | ||||
| α-16c | (CH2)10C8F17 | >250 | >3.3 (10%) | >3.3 |
| β-16a | (CH2)3C4F9 | >250 | >3.3 | >3.3 |
| β-16b | (CH2)10C6F13 | >250 | >3.3 (20%) | >3.3 (5%) |
| β-16c | (CH2)10C8F17 | >250 | >3.3 (5%) | >3.3 |
| Alkyl maltopyranosides | ||||
| β-17a | C7H15 | >250 | >3.3 | >3.3 |
| β-17b | C16H33 | 67 | 0.03 | 0.15 |
| Perfuoroalkyl maltopyranosides | ||||
| β-18a | (CH2)3C4F9 | >250 | >3.3 | >3.3 |
| β-18b | (CH2)10C6F13 | 25 | 1.7 | 2.5 |
| Positive control | ||||
| OTG | Octylthioglucoside | 620 | 0.5 | 3 |
