Table 5.

Risk factors for developing complicated sepsis

Factor	OR (95% CI)	p-value
Age	1.01 (1.00–1.02)	0.095
Male Sex	2.01 (1.27–3.31)	0.003
Injury Severity Score	1.03 (1.00–1.05)	0.030
Severe Thoracic Injury	1.86 (1.15–3.00)	0.011
Initial Base Deficit	1.09 (1.03–1.15)	0.002
Blood Transfusion (yes/no)	5.48 (3.01–9.99)	0.000
History of diabetes mellitus	3.01 (1.32–7.11)	0.009
Variant G allele TLR4 A896G SNP	0.29 (0.12–0.69)	0.005

The data presented are the result of stepwise logistic regression analysis. Clinical factors found to be important in determining the risk for complicated sepsis were male sex, injury severity score, severe thoracic injury as determined by an abbreviated injury severity score (AIS) greater than or equal to 3, initial base deficit measured in the emergency department, receiving a transfusion at any point during the hospital stay, and history of diabetes mellitus. Clinical variables that were included in the initial model but were found not to be important in determining the risk for complicated sepsis were age, severe head injury, and a history of cardiovascular or pulmonary disease.