Table 7.

Risk factors for developing complicated sepsis among Caucasian patients with post-traumatic sepsis (N = 598)

Factor	OR (95% CI)	p-value
Age	1.01 (1.00–1.02)	0.125
Male Sex	2.1 (1.27–3.31)	0.003
Injury Severity Score	1.03 (1.00–1.05)	0.027
Severe Thoracic Injury	1.9 (1.17–3.04)	0.009
Initial Base Deficit	1.0 (1.03–1.15)	0.002
Blood Transfusion (yes/no)	5.5 (2.98–9.95)	< 0.001
History of diabetes mellitus	2.9 (1.27–6.88)	0.012
Variant T allele of TLR4 htSNP2 (rs1927911)	6.1 (2.18–17.16)	0.001
Variant T allele of TLR4 htSNP4 (rs2149356)	0.2 (0.06–0.50)	0.001

The data presented are the result of stepwise logistic regression analysis. Carriage of the TLR4 896 variant was no longer associated with complicated sepsis after adjusting for TLR4 htSNP2 and htSNP4.