Table 1.

MICs of FTI, tobramycin and fosfomycin for Gram-positive and Gram-negative bacteria

	MIC (mg/L)
	FTI		tobramycin		fosfomycin
Organism (no. of strains)	range	MIC50 (MIC90)	range	MIC50 (MIC90)	range	MIC50 (MIC90)
S. aureusa (16)	0.5–16	2 (8)	0.125–512	0.5 (256)	0.125–16	2 (4)
S. pneumoniaea (8)	4–32	ND	16–64	ND	8–32	ND
S. pyogenesb (5)	16–32	ND	16–64	ND	16–64	ND
E. faecalisa (5)	32	ND	8–512	ND	32	ND
E. colia (22)	0.125–1	0.5 (1)	0.5–1	1 (1)	0.25–4	0.5 (2)
H. influenzaea (16)	≤0.13–4	0.5 (2)	0.5–1	1 (1)	0.25–4	0.5 (2)
Klebsiella spp.b (22)	0.5–16	1 (8)	0.13–>512	0.13 (16)	0.5–16	4 (16)
M. catarrhalisa (5)	0.5–1	ND	0.5–1	ND	4–16	ND
P. aeruginosaa, non-CF (60)	1–256	4 (128)	0.13–>512	1 (128)	1–>512	32 (128)
P. aeruginosaa, CF (100)	1–128	8 (64)	0.25–>512	2 (16)	4–>512	64 (512)
S. maltophiliaa (17)	8–256	64 (128)	2–>512	64 (256)	32–512	64 (128)
B. cepacia complexa (20)	0.5–>512	512 (>512)	1–>512	64 (512)	512–>512	>512 (>512)

ND, not determined due to the small number of isolates examined.

^aMICs were determined by the agar dilution method.

^bMICs were determined by the broth microdilution method.