Table 2.

Adjusted mean serum hormone concentrations by kidney dysfunction and kidney damage, US men aged ≥ 20 years, NHANES III, 1988–1991

	Kidney Dysfunction		Kidney Damage

	Normal eGFR ≥ 60 mL/min/1.73 m²	Decreased eGFR < 60 mL/min/1.73 m²	Elevated UACR ≥ 17 mg/g	Normal UACR < 17 mg/g
Testosterone (nmol/L)
Crude	19.3 ± 0.3	15.1 ± 0.7^*	16.7 ± 0.6^**	19.5 ± 0.3
Age-Adjusted	19.1 ± 0.2	19.5 ± 1.1	18.5 ± 0.7	19.2 ± 0.3
Multivariable Adjusted^†	18.0 ± 0.3	18.5 ± 0.8	17.3 ± 0.7	18.0 ± 0.3
Estradiol (pmol/L)
Crude	137.7 ± 2.7	135.9 ± 4.9	134.7 ± 6.7	137.9 ± 2.5
Age-Adjusted	137.3 ± 2.7	145.7 ± 5.7	138.6 ± 7.4	137.4 ± 2.4
Multivariable Adjusted^†	124.7 ± 3.3	137.3 ± 5.8^*	125.8 ± 8.5	125.2 ± 3.0
SHBG (nmol/L)
Crude	38.0 ± 0.8	48.9 ± 3.0^**	42.9 ± 2.2^*	37.9 ± 0.7
Age-Adjusted	38.4 ± 0.8	36.9 ± 2.9	37.9 ± 2.1	38.4 ± 0.76
Multivariable Adjusted^†	37.8 ± 0.9	35.9 ± 2.7	37.8 ± 2.3	37.8 ± 0.9
Molar Estradiol:Testosterone (x 10³)
Crude	9.9 ± 1.3	15.0 ± 3.8	15.6 ± 5.2	9.5 ± 1.2
Age-Adjusted	10.1 ± 1.3	10.6 ± 3.8	13.9 ± 5.4	9.7 ± 1.3
Multivariable Adjusted^†	10.8 ± 2.3	11.9 ± 3.6	15.7 ± 6.5	10.3 ± 2.1
Estimated Free Testosterone (nmol/L)
Crude	0.39 ± 0.006	0.26 ± 0.007^**	0.32 ± 0.014^**	0.39 ± 0.007
Age-Adjusted	0.38 ± 0.004	0.40 ± 0.015	0.39 ± 0.014	0.38 ± 0.004
Multivariable Adjusted^†	0.36 ± 0.004	0.39 ± 0.011^*	0.36 ± 0.015	0.36 ± 0.004
Estimated Free Estradiol (pmol/L)
Crude	3.54 ± 0.08	3.38 ± 0.10	3.39 ± 0.13	3.55 ± 0.07
Age-Adjusted	3.52 ± 0.08	3.81 ± 0.13	3.56 ± 0.16	3.53 ± 0.07
Multivariable Adjusted^†	3.17 ± 0.09	3.59 ± 0.14^*	3.19 ± 0.16	3.18 ± 0.08

p<0.05 compared to eGFR ≥ 60mL/min/1.73 m²

^**

p<0.0001 compared to eGFR ≥ 60 mL/min/1.73 m² or UACR <17 mg/g where appropriate

^†

Adjusted for age, race, systolic and diastolic blood pressures, percent body fat, smoking status, diabetes, hypertension medication use