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. Author manuscript; available in PMC: 2009 Sep 9.
Published in final edited form as: Clin Exp Allergy. 2008 Feb 4;38(5):839–846. doi: 10.1111/j.1365-2222.2008.02943.x

Fig. 4.

Fig. 4

Effect of PARP inhibition by TIQ-A on airway hyperreactivity in OVA-sensitized and challenged mice. C57BL/6 mice were sensitized to OVA and subjected to a challenge with aerosolized OVA (∎). A group of mice received an i.p. injection of TIQ-A (▴) or vehicle alone (●)after OVA exposure. Lung resistance to increasing doses of MeCh was assessed using the forced oscillation technique. Lung resistance is plotted as a function of increasing doses of inhaled MeCh, using single compartment model and expressed as mean ± SEM. n = 5 per group. *Difference from challenged mice without TIQ-A treatment, P < 0.01. PARP, poly(ADP-ribose) polymerase; TIQ-A, thieno[2,3-c]isoquinolin-5-one; BAL, bronchio-alveolar lavage; MeCh, methacholine; OVA, ovalbumin; i.p. intraperitoneally.