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Progressive bone loss in mature PNN mice. (a) 3-D reconstruction of metaphyseal trabecular bone in wild type (WT) versus PNN mice at different ages. (b) H&E staining of medial longitudinal sections through the tibia of 26-week-old mice. Arrows: bone trabeculae. Right panels: higher magnification of boxed regions in corresponding left panels. Double-lined arrows: chondrocytes. Vertical lines denote height of growth plate. Asterisk: area devoid of chondrocytes.
