TABLE 4.
Phenylalanine kinetics at baseline and during insulin infusion
| CTRL group |
EX group |
P |
|||||
|---|---|---|---|---|---|---|---|
| Basal | Insulin (nmol · min−1 · 100 ml leg−1) | Basal | Insulin (nmol · min−1 · 100 ml leg−1) | Group | Time | Interaction | |
| Delivery to the leg | 156 ± 12 | 145 ± 8 | 234 ± 43 | 309 ± 47 | 0.01 | <0.01 | <0.01 |
| Output from the leg | 171 ± 13 | 149 ± 10 | 255 ± 46 | 300 ± 45 | 0.02 | 0.23 | <0.01 |
| Release in the blood from proteolysis (Ra) | 63 ± 10 | 44 ± 9 | 66 ± 14 | 70 ± 19 | 0.32 | 0.21 | 0.04 |
| Disappearance from the blood (Rd) | 48 ± 9 | 40 ± 7 | 45 ± 11 | 79 ± 19 | 0.22 | 0.02 | <0.01 |
| Muscle inward transport | 113 ± 20 | 75 ± 11 | 193 ± 46 | 250 ± 47 | 0.01 | 0.47 | 0.02 |
| Muscle outward transport | 128 ± 21 | 79 ± 11 | 214 ± 48 | 241 ± 45 | 0.01 | 0.62 | 0.05 |
| Arteriovenous shunting | 43 ± 11 | 70 ± 12 | 41 ± 13 | 59 ± 28 | 0.76 | 0.06 | 0.77 |
| Intracellular availability | 186 ± 27 | 136 ± 21 | 263 ± 58 | 330 ± 60 | 0.03 | 0.49 | <0.01 |
| Release from muscle protein breakdown | 73 ± 9 | 61 ± 14 | 70 ± 14 | 80 ± 23 | 0.55 | 0.95 | 0.18 |
| Utilization for muscle protein synthesis | 58 ± 8 | 57 ± 12 | 49 ± 11 | 89 ± 23 | 0.44 | 0.02 | 0.03 |
| Net balance | −15 ± 2 | −2 ± 2 | −21 ± 4 | 9 ± 4 | 0.43 | <0.0001 | <0.01 |
Data are means ± SE. Boldface data indicate statistical significance.