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. Author manuscript; available in PMC: 2010 Oct 6.
Published in final edited form as: Neuroscience. 2009 Jun 23;163(2):705–718. doi: 10.1016/j.neuroscience.2009.06.046

Figure 7.

Figure 7

Effect of local DPN- or E-treatment on tph2 mRNA levels of OVX females. DPN and E both act locally to enhance tph2 expression in mid- and caudal subregions of the DRN. The table in panel A lists densitometry-determined values for tph2 mRNA expression in seven subregions throughout the rostro-caudal extent of the DRN (regular letters). For the rostral, mid and caudal DRN, the sum of respective subregional values is displayed in bold letters. OVX rats were implanted with DRN-flanking wax pellets containing nothing (vehicle group), E or DPN. An additional control group remained without brain surgery. Numbers in parentheses indicate group size. Each value represents the mean ± SEM. Panel B: This diagram is a graphic illustration of tph2 mRNA expression levels in the rostral, mid and caudal DRN, as listed in bold letters in Panel A. Each value represents the mean ± SEM. * (p < 0.05) and ** (p < 0.01) indicate significance versus vehicle controls, + (p < 0.05) and ++ (p < 0.01) versus unoperated controls, and # (p < 0.05) and ## (p < 0.01) versus E-treated animals. C = OVX control group without brain surgery (n=7), Veh = vehicle control group (blank wax pellets, n=9), E = estradiol-treated animals (n=10), DPN = DPN-treated animals (n=10). ANOVA (factor treatment) was performed, followed by Tukey’s post hoc test where appropriate.