Figure 7.

PCs cycle faster at early time points of neurogenesis and slower at later gestational time points in tlx-deficient animals. Comparisons of the change in the LI (percentage of BrdU incorporation; y-axis) over time (embryonic age; x-axis) in wild-type (black) versus mutant (gray) animals for rostral (A), intermediate (B), and caudal (C) levels. D, Regression analysis showing that the change in VZ PC proliferation over time in the caudal region of wild-type versus mutant animals is significantly different. The slope for the mutant is –1.84 and for the wild type is –0.08. In contrast, the SVZ (dashed lines) is significantly reduced at all rostrocaudal levels. p < 0.05; **p < 0.01; ***p < 0.001.