Table 2.

Allele frequencies for rs1800795 (IL-6 promoter) and rs8192284 (IL-6 receptor) SNP in high risk neuroblastoma (NBL) patients. Allele frequencies of two SNP known to impact IL-6 signaling events were compared between high risk NBL patients and those published in other population-based studies. While similar frequencies were noted between the IL-6 receptor SNP (rs8192284), a statistically significant shift toward G/G was observed the promoter SNP (rs1800795) in high risk NBL patients compared to the general population (P-value = 0.0003; see text for more details).

Allele Frequencies
Genotype	High Risk Neuroblastoma Samples (%)	Population (%) (ref: *28–30; †27)
-174 IL-6 (G>C) (rs1800795)
G/G	55 (57.3)	*37.1
G/C	33 (34.4)	*45.2
C/C	8 (8.3)	*17.7
D358A IL6R (rs8192284)
A/A	41 (42.7)	†34.5
A/C	52 (54.2)	†49.7
C/C	3 (3.1)	†15.8