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. 2009 May 20;29(20):6394–6405. doi: 10.1523/JNEUROSCI.4909-08.2009

Figure 8.

Figure 8.

Brain mitochondria from 10-month-old AD transgenic mice exhibit increased cholesterol and depleted GSH levels. A, Total cholesterol levels. B, GSH levels of isolated brain mitochondria from WT mice and AD transgenic mice (Tg-APP/PS1) at the indicated ages. *p < 0.05 (n = 3–4). C, D, SREBP-2 expression in brain extracts from WT mice and Tg-APP/PS1 transgenic mice at the indicated ages. C, SREBP-2 mRNA expression analyzed by real-time PCR. Relative values were normalized against 18 s expression. *p < 0.05 (n = 3–4). D, Representative immunoblotting showing SREBP-2 protein levels. β-Actin levels were analyzed as a loading control. Values are mean ± SD; mean differences were compared by unpaired Student's t test. prot., Protein.