Table 3.

I/R-induced hemodynamic changes in age-matched control, diabetic (DM), and insulin-treated diabetic (DMI) rats measured by Millar pressure-volume conductance catheter system.

	Control (n = 7)	DM (n = 9)	DMI (n = 8)
Heart rate (bpm)	366 ± 12	263 ± 12*(P < 0.001)	299 ± 12
End-systolic volume (μL)	253 ± 42	233 ± 35	219 ± 37
End-diastolic volume (μL)	311 ± 45	286 ± 32	279 ± 39
Maximum pressure (mmHg)	90 ± 3	71 ± 4.4*(P < 0.01)	75 ± 4.4
Minimum pressure (mmHg)	2.54 ± 0.46	1.74 ± 0.4	2.86 ± 1.86
End-systolic pressure (mmHg)	87 ± 2.9	66 ± 4.9*(P < 0.01)	70 ± 3.9
End-diastolic pressure (mmHg)	6.98 ± 0.92	4.9 ± 0.41*(P < 0.05)	6.76 ± 2.02
Stroke volume (μL)	94 ± 13	84 ± 9.2	92 ± 9.3
Ejection fraction (%)	30.8 ± 4.53	31.3 ± 4.44	33.4 ± 3.95
Cardiac output (μL/min)	33,914 ± 4,240	22,504 ± 3,263*(P < 0.05)	27,342 ± 2,848
Stroke work (mmHg*μL)	5,501 ± 914	4,031 ± 601	4,640 ± 720
Arterial elastance (mmHg/μL)	1.04 ± 0.15	0.9 ± 0.17	0.82 ± 0.07
End-systolic elastance (mmHg/μL)	0.893 ± 0.179	0.484 ± 0.071*(P < 0.05)	0.822 ± 0.166
dPdt max (mmHg/sec)	4,956 ± 292	3,738 ± 298*(P < 0.05)	4,523 ± 639
dPdt min (mmHg/sec)	-3,944 ± 279	-3,002 ± 414	-3,054 ± 303
P@dPdt max (mmHg)	49.53 ± 3.25	39.19 ± 2.93	42.91 ± 4.54
Tau_w (msec)	11.44 ± 0.86	16.71 ± 1.29*(P < 0.1)	13.51 ± 1.45
Tau_g (msec)	14.73 ± 1.65	24.07 ± 0.92*(P < 0.05)	16.62 ± 0.71†(P < 0.05)

Data are expressed as means ± SEM (*, vs. control; †, vs. DM). DM, STZ-diabetes; DMI, insulin-treated diabetes.