Table 3 Genotype/haplotype frequencies, log10 total serum IgE and plasma eotaxin levels with respect to +67G/A, –384A/G and –427C/T polymorphisms and the risk haplotype in eotaxin gene.
| Genotypes | Genotype frequencies of different genotypes in case–control studies | †Log10 TsIgE levels with respect to different genotypes | Plasma eotaxin levels with respect to different genotypes | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patients* | Controls* | Common OR | p Value | Log10 TsIgE levels (±SE) | No of individuals (n) | Overall p Value | Plasma eotaxin levels (±SE) (pg/ml) | No. of individuals (n) | Overall p Value | |
| +67G/A | ||||||||||
| AA | 0 (0.0) | 2 (0.84) | 2.00 (0.41) | 2 | 7 (75) | 1 | ||||
| GA | 47 (20.35) | 70 (29.54) | 1.96 | 0.0086 | 2.55 (0.06) | 104 | 0.42 | 113 (13) | 34 | 0.0057 |
| GG | 184 (79.65) | 165 (69.62) | 2.54 (0.04) | 301 | 153 (7) | 104 | ||||
| −384A/G | ||||||||||
| GG | 55 (23.5) | 57 (24.05) | 2.41 (0.06) | 107 | 124 (13) | 33 | ||||
| GA | 127 (54.27) | 105 (44.3) | 0.843 | 0.176 | 2.58 (0.04) | 202 | 0.016 | 134 (9) | 71 | 0.0072 |
| AA | 52 (22.22) | 75 (31.65) | 2.61 (0.06) | 100 | 177 (13) | 35 | ||||
| −427C/T | ||||||||||
| TT | 14 (5.96) | 16 (6.69) | 2.52 (0.12) | 26 | 128 (29) | 7 | ||||
| CT | 85 (36.17) | 84 (35.15) | 0.975 | 0.936 | 2.51 (0.05) | 138 | 0.58 | 134 (12) | 43 | 0.43 |
| CC | 136 (57.87) | 139 (58.16) | 2.57 (0.04) | 248 | 149 (8) | 88 | ||||
| Haplotype | ||||||||||
| GAC8/GAC8 | 7 (3.13) | 0 (0) | 3.15 (0.24) | 6 | 336 (52) | 2 | ||||
| GAC8/Non GAC8 | 47 (20.98) | 20 (8.93) | 5.01 | <0.0001 | 2.65 (0.08) | 59 | 0.013 | 161 (8) | 80 | <0.0001 |
| Non GAC8/Non GAC8 | 170 (75.89) | 204 (91.07) | 2.52 (0.03) | 324 | 134 (5) | 192 | ||||
TsIgE, total serum IgE.
*Numbers in parentheses indicate the frequency (%).
†Analysis with Log10 TsIgE (total serum IgE) levels was done irrespective of the asthma status.