Table 1.

Association between Baseline Factors and Graft Failure According to Corneal Diagnosis

			Preoperative Diagnosisa
	Total		Fuchs’ Dystrophy		Pseudophakic/Aphakic corneal edema
Baseline Factors	N	5-yr Graft Failureb± 95% CI	N	5-yr Graft Failureb± 95% CI	N	5-yr Graft Failureb± 95% CI
Overall	1,090	14% ± 2%	676	7% ± 2%	369	27% ± 5%
Gender
Male	393	14% ± 4%	210	7% ± 4%	158	24% ± 7%
Female	697	14% ± 3%	466	8% ± 3%	211	29% ± 7%
Race/Ethnicity
White (Non-Hispanic)	1,011	13% ± 2%	651	7% ± 2%	322	26% ± 5%
Non-White (including Hispanic)	79	29% ± 11%	25	18% ± 16%	47	36% ± 16%
Black	50	35% ± 15%	19	24% ± 21%	27	42% ± 22%
Hispanic	13	*	2	*	9	*
Other	16	8% ± 14%	4	*	11	*
Age at Surgery
<60 years	162	12% ± 5%	126	5% ± 4%	29	48% ± 20%
60–<70 years	284	10% ± 4%	201	8% ± 4%	70	14% ± 9%
≥70 years	644	16% ± 3%	349	8% ± 3%	270	28% ± 6%
Smoker (at time of surgery)
No	988	13% ± 2%	628	7% ± 2%	325	27% ± 5%
Yes	102	19% ± 8%	48	9% ± 8%	44	30% ± 15%
History of Diabetesc
No	899	13% ± 2%	587	7% ± 2%	276	26% ± 6%
Yes	141	15% ± 6%	67	7% ± 7%	69	24% ± 11%
Post-operative Intraocular Pressured
≤25 mmHg	953	13% ± 2%	608	7% ± 2%	301	25% ± 5%
>25 mmHg	130	23% ± 8%	63	10% ± 8%	66	36% ± 13%
Prior Glaucoma Surgery/Medications
No Medications and No Surgery	920	11% ± 2%	627	7% ± 2%	259	22% ± 6%
Medications and No Surgery	99	20% ± 9%	34	16% ± 13%	61	20% ± 11%
No Medications and Surgery	26	29% ± 18%	8	*	15	43% ± 26%
Medications and Surgery	45	58% ± 16%	7	*	34	67% ± 18%
Recipient Bed Sizee
<8.0 mm	464	17% ± 4%	240	9% ± 4%	198	27% ± 7%
=8.0 mm	523	11% ± 3%	365	6% ± 3%	144	27% ± 8%
>8.0 mm	102	13% ± 7%	70	8% ± 6%	27	30% ± 19%
Vitrectomy During Transplant
No	931	12% ± 2%	645	7% ± 2%	242	25% ± 6%
Yes	159	28% ± 8%	31	17% ± 14%	127	32% ± 9%

CI = Confidence interval

^*= Graft failure rates not reported for groups with N < 15.

^a45 subjects with “Other” diagnosis not included.

^bKaplan-Meier estimates.

^c50 subjects with unknown history of diabetes.

^dMaximum intraocular pressure during initial 30 days following surgery. Missing intraocular pressure measurements for 7 subjects.

^e1 subject with missing recipient bed size.