Table 2.

Multivariate Analysis of Baseline Factors Predictive of Graft Failure

		Univariate Models			Multivariate Models
					Model 1a			Model 2b
Baseline Factors	N	Hazard Ratio	95% CI	P- value	Hazard Ratio	95% CI	P- value	Hazard Ratio	95% CI	P- value
Race/Ethnicity				<0.001			0.02			0.05
White (Non-Hispanic)	1011	1.00			1.00			1.00
Non-White (including Hispanic)	79	2.60	1.60, 4.22		1.82	1.09, 3.04		1.65	1.01, 2.71
Diagnosis				<0.001			<0.001			<0.001
Fuchs’ Dystrophy	676	1.00			1.00			1.00
Pseudophakic/Aphakic Corneal Edema	369	4.08	2.84, 5.85		2.75	1.78, 4.25		3.12	2.12, 4.60
Other	45	2.31	0.99, 5.41		1.63	0.68, 3.94		1.66	0.70, 3.93
Glaucoma History				<0.001			<0.001			<0.001
No Medications and No Surgery	920	1.00			1.00			1.00
Medications and No Surgery	99	1.97	1.17, 3.31		1.26	0.73, 2.17		1.27	0.75, 2.17
No Medications and Surgery	26	2.97	1.38, 6.42		2.13	0.96, 4.71		2.01	0.92, 4.39
Medications and Surgery	45	7.18	4.49, 11.46		3.84	2.30, 6.42		4.18	2.56, 6.83
Gender				0.88			0.37
Male	393	1.00			1.00
Female	697	1.03	0.72, 1.46		1.18	0.82, 1.71
Age at Surgery				0.08			0.30
<60 years	162	1.00			1.00
60–<70 years	284	0.81	0.45, 1.46		0.70	0.38, 1.27
≥70 years	644	1.30	0.79, 2.13		0.97	0.58, 1.63
Smoker (at time of surgery)				0.11			0.16
No	988	1.00			1.00
Yes	102	1.52	0.92, 2.53		1.47	0.87, 2.48
History of Diabetesc				0.46			0.70
No	899	1.00			1.00
Yes	141	1.21	0.73, 1.99		0.90	0.54, 1.51
Post-operative Intraocular Pressured				0.04			0.48
≤25 mmHg	953	1.00			1.00
> 25 mmHg	130	1.89	1.23, 2.91		1.18	0.75, 1.86
Vitrectomy				<0.001			0.21
No	931	1.00			1.00
Yes	159	2.59	1.78, 3.77		1.31	0.86, 1.99
Recipient Bed Sizee (per mm)				0.01			0.76
< 8.0 mm	464	1.00			1.00
= 8.0 mm	523	0.65	0.46, 0.93		0.91	0.63, 1.32
> 8.0 mm	102	0.75	0.40, 1.38		1.12	0.59, 2.12

CI = Confidence interval

^aInitial multivariate model included all variables listed in Table 1 regardless of level of significance.

^bThe final multivariate model was generated through backward elimination of variables, if level of significance was >0.05.

^cUnknown for 50 subjects.

^dMaximum intraocular pressure value during initial 30 days following surgery. P-value obtained by treating IOP measurements as continuous variable in the univariate Cox model. IOP measurements missing for 7 subjects.

^eP-value obtained by treating the recipient bed size as continuous variable in the univariate Cox model. Recipient bed size missing for 1 subject.