Table 1.
Description of subjects by level of kidney function. Results are expressed as frequencies, mean ± standard deviation or median (interquartile range) as appropriate.
| Variables | eGFR >60 N=58 |
eGFR 45-60 N=34 |
eGFR 30-44 N=69 |
eGFR < 30 N=59 |
P (trend) |
|---|---|---|---|---|---|
| Age | 57 ± 17 | 60 ± 10 | 64 ± 11 | 65 ± 12 | <0.001 |
| Female gender (%) | 43 | 21 | 32 | 37 | 0.10 |
| Black (%) | 7 | 59 | 43 | 21 | 0.10 |
| eGFR (ml/min/1.73 m2) | 93 ± 23 | 53 ± 5 | 37 ± 5 | 23 ± 6 | <0.001 |
| Blood pressure (mmHg) | |||||
| Systolic | 120 ± 17 | 135 ± 19 | 134 ± 20 | 135 ± 22 | <0.001 |
| Diastolic | 68 ± 13 | 76 ± 10 | 76 ± 11 | 75 ± 13 | 0.002 |
| Body mass index (kg/m2) | 28 ± 7 | 32 ± 6 | 31 ± 7 | 29 ± 7 | 0.87 |
| Co-morbidities (%) | |||||
| Diabetes | 19 | 62 | 52 | 39 | 0.04 |
| Hypertension | 57 | 85 | 93 | 95 | <0.001 |
| Coronary artery disease | 14 | 6 | 19 | 17 | 0.32 |
| Congestive heart failure | 14 | 6 | 9 | 7 | 0.25 |
| Tobacco use* | 55 | 66 | 64 | 68 | 0.12 |
| Medications (%) | |||||
| Anti-hypertensive | 59 | 80 | 75 | 71 | 0.01 |
| Phosphorus binders | 0 | 0 | 0 | 15 | <0.001 |
| Activated Vitamin D | 0 | 3 | 9 | 25 | 0.001 |
| Laboratory values | |||||
| Creatinine (mg/dl) | 0.9 ± 0.2 | 1.5 ± 0.2 | 1.9 ± 0.3 | 3.0 ± 1.5 | <0.001 |
| Calcium (mg/dl) | 9.2 ± 0.5 | 9.1 ± 1.2 | 9.4 ± 0.5 | 9.4 ± 0.6 | 0.01 |
| Albumin (mg/dl) | 3.4 ± 0.5 | 3.8 ± 1.1 | 3.9 ± 0.5 | 3.8 ± 0.6 | 0.005 |
| PTH (pg/ml) | 40 (29, 58) | 79 (50, 135) | 64 (41, 95) | 73 (49, 104) | <0.001 |
*
includes current and former smokers
eGFR, estimated glomerular filtration rate; PTH, parathyroid hormone