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. Author manuscript; available in PMC: 2009 Sep 10.
Published in final edited form as: Mol Cancer Res. 2008 Oct;6(10):1521–1533. doi: 10.1158/1541-7786.MCR-07-2203

FIGURE 6.

FIGURE 6

Ron and c-Met receptors cooperate to mediate HGF- induced mammary tumor cell scattering, motility and invasion. 4T1 tumor cells were treated with Control (serum free medium) or HGF in the presence or absence of control goat IgG (1μg/ml) or neutralizing antibodies (1μg/ml) to c- Met and Ron, and assessed for the ability to A. scatter B. invade across a Matrigel coated membrane. Pixel density of invaded cells was measured by Image J software. Statistical significance was determined by Two Tailed T-test: *vs. HGF/IgG; p<0.01, **vs. HGF/IgG; p<0.01, and Two Way ANOVA Test: ***vs. HGF/anti-c-Met and HGF/anti-Ron treatments; p<0.05. Data are represented as mean±SEM.