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. Author manuscript; available in PMC: 2009 Sep 10.
Published in final edited form as: Mol Cancer Res. 2008 Oct;6(10):1521–1533. doi: 10.1158/1541-7786.MCR-07-2203

FIGURE 7.

FIGURE 7

Ron and c-Met receptors signal independently to activate MAPK and Stat3 pathways in 4T1 carcinoma cells. 4T1 cells were treated with control (serum free medium) or HGF in the presence of absence of the following c-Met and Ron inhibitors and analyzed by western blot analysis for the phosphorylated status of indicated proteins: A. Treatment of cells with 250 nM EXEL-7592 or control KDR inhibitor EXEL-1075 B. Treatment of cells with neutralizing antibodies to c-Met and Ron. C. siRNA silencing of c-Met and Ron. Expression of c-Met and Ron was quantified by densitometry analysis of western blots and is shown as a percentage of expression relative to c-Met and Ron expression in 4T1 Parental cells. Representative results of triplicate experiments are shown.