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. Author manuscript; available in PMC: 2009 Sep 10.
Published in final edited form as: Mol Cancer Res. 2008 Oct;6(10):1521–1533. doi: 10.1158/1541-7786.MCR-07-2203

FIGURE 9.

FIGURE 9

Model of TGF-β and HGF signaling in fibroblast: tumor interactions. A. Cre mediated deletion of the TGF-β type II receptor in mammary fibroblasts inhibits TGF-β signaling, resulting in upregulated HGF expression at the RNA level as well as protein secretion [17,26] B. HGF binds to c-Met directly as may interact with Ron indirectly to enhance c-Met and Ron mediated downstream signaling in mammary epithelial cells. C. Increased cooperative interactions between Stat3 and p42/44MAPK signaling results in mammary carcinoma cell scattering, motility and invasion, important processes involved in metastatic spread.