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MBH leucine and KIC injections reduce food intake and body weight in rat and mouse. a–h, Cumulative (Cum.) food intake (a, e), 24 h change in body weight (BW) (b, f), mean meal size (c, g), and cumulative meal number (d, h) in rat (a–d, n = 10–12) and mouse (e–h, n = 8) following an MBH injection of aCSF, leucine, or KIC (injection design 1). Data are means ± SEM. *p < 0.05 versus aCSF; **p < 0.01 versus aCSF; ***p < 0.001 versus aCSF.
