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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Mol Immunol. 2009 May 23;46(11-12):2256–2266. doi: 10.1016/j.molimm.2009.04.008

Fig. 1.

Fig. 1

β3AR stimulation up-regulates IL-6 production in adipocytes. 3T3-L1 cells treated with the β3AR-agonist CL316243 (1 μM for 45 min) showed a significant increase in IL-6 mRNA. The CL316243-induced increase in cytokine transcripts was completely blocked by pre-treatment with SR59230A (1 μM for 1 h) but not with betaxolol (0.5 μM for 1 h) or ICI118,551 (0.5 μM for 1 h) (a). 3T3-L1 cells treated with the β3AR-agonist CL316243 (1 μM for 24 and 48 h) showed a significant increase in IL-6 protein measured in cell supernatant (b). ***P<0.001 different from untreated.