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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Nanomedicine (Lond). 2009 Jun;4(4):391–399. doi: 10.2217/nnm.09.14

Figure 4. Quantitative energy-filtered transmission electron microscopic imaging of dendrimer nanoparticles.

Figure 4

(A) Principle of energy-filtered transmission electron microscopy (EFTEM) image formation. A broad electron beam illuminates a specimen of nanoparticles deposited onto an ultra-thin carbon substrate, exciting inner-shell electrons of specific atoms. A magnetic prism disperses the transmitted electrons according to energy loss, and a slit selects those electrons of a particular energy loss range. An energy-filtered image is formed at the CCD detector plane by lenses after the slit. (B) Energy-loss spectrum around gadolinium (Gd) core-loss edge obtained from a thick layer of Gd-G7 dendrimers. (C) Example EFTEM image of Gd distributions in dendrimer nanoparticles. Scale bar is 100 nm.