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. Author manuscript; available in PMC: 2010 Jun 30.
Published in final edited form as: Biochemistry. 2009 Jun 30;48(25):5943–5952. doi: 10.1021/bi900204w

Figure 4.

Figure 4

(A) The crystal structure of the RT-DNA-CD27 complex. The asymmetric unit consists of one protein molecule, 8 base pairs of the symmetric 16 base pair oligonucleotide duplex, and one CD27 molecule representing half of the symmetric complex. The dashed vertical line represents the dyad. The DNA oligonucleotide is shown as a gray stick model and CD27 is shown in a red stick model. RT is shown as a ribbon rendering with beta strands, alpha-helices and coils in navy. Residues Tyr64, Asp114, Lue115, Arg116, and Gly191 make contacts with the DNA and are shown as an orange ball-and-stick model. (B) Schematic of the oligonucleotide duplex with the two complementary strands and numbering scheme referred to in the text. Arrow denotes span of CD27 binding to oligonucleotide.