Table 2.
Numbers of cases and controls and adjusted odds ratios* for risk of cancer according to numbers of prescriptions of non-steroidal anti-inflammatory drugs received in 13-24 and 25-36 months before diagnosis and both periods combined
| Site | Total No | Months 13-24
|
Months 25-36
|
Months 13-36
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of prescriptions
|
P for trend | No of prescriptions
|
P for trend | No of prescriptions
|
P for trend | |||||||||||||
| 0 | 1 | 2-6 | ⩾7 | 0 | 1 | 2-6 | ⩾7 | 0 | 1 | 2-6 | ⩾7 | |||||||
| Oesophagus: | ||||||||||||||||||
| No of cases (controls) | 550 (1650) | 451 (1314) | 37 (111) |
41 (142) |
21 (83) |
0.10 | 455 (1330) | 45 (107) |
28 (128) |
22 (85) |
0.07 | 414 (1199) | 56 (150) | 49 (164) | 31 (137) | 0.03 | ||
| Odds ratio (95% CI) | 1.00 | 0.90 (0.59 to 1.35) | 0.82 (0.56 to 1.19) | 0.72 (0.42 to 1.22) | 1.00 | 1.23 (0.83 to 1.80) | 0.65 (0.42 to 0.99) | 0.72 (0.43 to 1.20) | 1.00 | 1.04 (0.74 to 1.46) | 0.82 (0.57 to 1.17) | 0.64 (0.41 to 0.98) | ||||||
| Stomach: | ||||||||||||||||||
| No of cases (controls) | 613 (1837) | 508 (1491) | 50 (129) |
33 (122) |
22 (95) |
0.03 | 509 (1499) | 46 (118) |
42 (128) |
16 (92) |
0.02 | 465 (1365) | 57 (159) | 60 (156) | 31 (157) | 0.02 | ||
| Odds ratio (95% CI) | 1.00 | 1.08 (0.75 to 1.54) | 0.72 (0.47 to 1.10) | 0.61 (0.36 to 1.02) | 1.00 | 1.14 (0.79 to 1.63) | 0.80 (0.54 to 1.19) | 0.49 (0.27 to 0.86) | 1.00 | 1.07 (0.77 to 1.48) | 1.02 (0.73 to 1.42) | 0.51 (0.33 to 0.79) | ||||||
| Pancreas: | ||||||||||||||||||
| No of cases (controls) | 513 (1535) | 410 (1238) | 38 (113) |
37 (127) |
28 (57) |
0.34 | 406 (1276) | 41 (97) |
41 (114) |
25 (48) |
0.10 | 367 (1139) | 46 (147) | 50 (142) | 50 (107) | 0.08 | ||
| Odds ratio (95% CI) | 1.00 | 1.05 (0.70 to 1.56) | 0.88 (0.59 to 1.32) | 1.58 (0.96 to 2.59) | 1.00 | 1.28 (0.85 to 1.92) | 1.14 (0.76 to 1.70) | 1.50 (0.87 to 2.56) | 1.00 | 0.94 (0.64 to 1.36) | 1.08 (0.75 to 1.54) | 1.49 (1.02 to 2.18) | ||||||
| Colon: | ||||||||||||||||||
| No of cases (controls) | 1368 (4089) | 1116 (3255) | 108 (322) | 100 (340) | 44 (172) |
0.02 | 1101 (3309) | 124 (280) | 93 (335) |
50 (165) |
0.41 | 990 (2939) | 157 (409) | 138 (431) | 83 (310) | 0.09 | ||
| Odds ratio (95% CI) | 1.00 | 0.96 (0.76 to 1.22) | 0.81 (0.63 to 1.04) | 0.74 (0.52 to 1.05) | 1.00 | 1.26 (1.00 to 1.59) | 0.83 (0.65 to 1.07) | 0.91 (0.64 to 1.27) | 1.00 | 1.11 (0.90 to 1.36) | 0.93 (0.75 to 1.15) | 0.76 (0.58 to 1.00) | ||||||
| Rectum: | ||||||||||||||||||
| No of cases (controls) | 593 (1778) | 490 (1442) | 50 (142) |
35 (115) |
18 (79) |
0.17 | 488 (1442) | 46 (140) |
45 (129) |
14 (67) |
0.31 | 441 (1296) | 70 (196) | 51 (161) | 31 (125) | 0.18 | ||
| Odds ratio (95% CI) | 1.00 | 1.01 (0.71 to 1.44) | 0.88 (0.59 to 1.32) | 0.68 (0.40 to 1.16) | 1.00 | 0.96 (0.67 to 1.39) | 1.00 (0.69 to 1.44) | 0.65 (0.36 to 1.18) | 1.00 | 1.07 (0.79 to 1.46) | 0.87 (0.61 to 1.23) | 0.75 (0.49 to 1.14) | ||||||
| Bladder: | ||||||||||||||||||
| No of cases (controls) | 1041 (3122) | 827 (2561) | 84 (218) |
88 (221) |
42 (122) |
0.26 | 829 (2569) | 80 (212) |
90 (217) |
42 (124) |
0.28 | 741 (2351) | 118 (270) | 104 (292) | 78 (209) | 0.14 | ||
| Odds ratio (95% CI) | 1.00 | 1.21 (0.92 to 1.59) | 1.20 (0.91 to 1.58) | 1.01 (0.69 to 1.48) | 1.00 | 1.10 (0.83 to 1.45) | 1.24 (0.95 to 1.63) | 0.99 (0.68 to 1.45) | 1.00 | 1.38 (1.08 to 1.75) | 1.09 (0.84 to 1.40) | 1.14 (0.85 to 1.53) | ||||||
| Breast: | ||||||||||||||||||
| No of cases (controls) | 3105 (9272) | 2464 (7400) | 269 (782) | 240 (755) | 132 (335) | 0.48 | 2484 (7428) | 271 (836) | 229 (686) | 121 (322) | 0.56 | 2195 (6574) | 376 (1120) | 313 (979) | 221 (599) | 0.64 | ||
| Odds ratio (95% CI) | 1.00 | 1.03 (0.88 to 1.20) | 0.95 (0.81 to 1.12) | 1.17 (0.94 to 1.45) | 1.00 | 0.96 (0.82 to 1.11) | 1.01 (0.85 to 1.18) | 1.12 (0.90 to 1.40) | 1.00 | 0.99 (0.87 to 1.13) | 0.96 (0.83 to 1.11) | 1.10 (0.92 to 1.30) | ||||||
| Lung: | ||||||||||||||||||
| No of cases (controls) | 2560 (7643) | 2092 (6207) | 181 (550) | 187 (552) | 100 (334) | 0.16 | 2109 (6239) | 187 (526) | 168 (564) | 96 (314) |
0.10 | 1903 (5631) | 235 (750) | 250 (685) | 172 (577) | 0.17 | ||
| Odds ratio (95% CI) | 1.00 | 0.90 (0.74 to 1.09) | 0.95 (0.79 to 1.15) | 0.87 (0.68 to 1.11) | 1.00 | 1.03 (0.86 to 1.25) | 0.87 (0.71 to 1.05) | 0.86 (0.67 to 1.11) | 1.00 | 0.85 (0.72 to 1.01 | 1.05 (0.89 to 1.24) | 0.84 (0.69 to 1.02) | ||||||
| Prostate: | ||||||||||||||||||
| No of cases (controls) | 1813 (5354) | 1386 (4400) | 178 (366) | 167 (368) | 82 (220) |
0.001 | 1422 (4420) | 152 (352) | 167 (376) | 72 (206) |
0.002 | 1243 (4004) | 220 (485) | 201 (492) | 149 (373) | 0.0001 | ||
| Odds ratio (95% CI) | 1.00 | 1.49 (1.22 to 1.82) | 1.44 (1.17 to 1.76) | 1.21 (0.92 to 1.60) | 1.00 | 1.36 (1.10 to 1.67) | 1.34 (1.09 to 1.64) | 1.17 (0.87 to 1.55) | 1.00 | 1.43 (1.19 to 1.71) | 1.28 (1.06 to 1.54) | 1.33 (1.07 to 1.64) | ||||||
| All sites: | ||||||||||||||||||
| No of cases (controls) | 12 174 (34 934) |
9760 (28 251) | 996 (2642) | 929 (2635) | 489 (1406) | 0.75 | 9820 (28 449) | 992 (2594) | 903 (2547) | 459 (1344) | 0.80 | 8775 (25 541) | 1336 (3597) | 1216 (3325) | 847 (2471) | 0.64 | ||
| Odds ratio (95% CI) | 1.00 | 1.08 (0.99 to 1.17) | 1.00 (0.91 to 1.08) | 1.00 (0.89 to 1.12) | 1.00 | 1.09 (1.00 to 1.18) | 1.00 (0.91 to 1.09) | 0.98 (0.87 to 1.10) | 1.00 | 1.06 (0.99 to 1.14) | 1.04 (0.96 to 1.12) | 0.98 (0.89 to 1.07) | ||||||
*
Adjusted for age and smoking status.