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Synthesis of NP-DO3AMa
a Reagents and conditions: i. (Boc)2O/CHCl3 (90%), ii. BnOCOCl/Et3N/CHCl3 (98%), iii. HCl/MeOH (94%), iv. BrCH2CONH2/MeCN/K2CO3 (90%), v. H2/10% Pd on C/EtOH (99%), vi. 2-hydroxyl-5-nitrobenzyl bromide/K2CO3/EtOH (65%).
