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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Cancer Res. 2009 Jun 23;69(14):5743–5751. doi: 10.1158/0008-5472.CAN-08-3564

Figure 3.

Figure 3

RGS4 selectively inhibits Rac-activated lamellipodia formation in breast cancer cells. A and B, RGS4 blocks lamellipodia formation and the translocation of cortactin to lamellipodia by inhibiting Rac activity in MDA-MB-231 cells. Arrows, lamellipodia at cell edges (A). Scale bar, 50 μm. B, lamellipodial extent at cell leading edges was quantified as fraction of cell circumference on 20 randomly selected cells in each group. Columns, means; bars, SE (n = 3), *, P < 0.001 compared with control. C, representative image of Western blot of total (10%) and active GTP-bound Rac1 and RhoA (n = 3) in MDA-MB-231 control cells and cells expressing RGS4 or RGS4-N128A.