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. 2003 Apr 29;88(9):1381–1387. doi: 10.1038/sj.bjc.6600882

Table 4. Relative risks (RRs) of melanoma by daily servings of fruits and vegetables and by frequency of consumption of orange juice.

  Cases Person-years (thousands) Multivariateb RR (95% CIc)
Total fruits      
<1.0 62 349 1.00
1.0–1.4 58 274 1.16 (0.80–1.66)
1.5–2.4 151 524 1.42 (0.99–2.04)
2.5–3.4 83 303 1.37 (0.95–1.98)
⩾3.5 60 198 1.37 (0.86–2.20)
P for linear trend     0.22
       
Total vegetables      
<2.0 86 448 1.00
2.0–2.9 126 479 1.22 (0.92–1.62)
3.0–3.9 106 356 1.32 (0.97–1.78)
4.0–4.9 53 196 1.11 (0.76–1.62)
⩾5.0 43 169 1.01 (0.68–1.50)
P for linear trend     0.81
       
Fruits and vegetables high in carotenoids      
<0.25 50 263 1.00
0.25–0.49 116 447 1.30 (0.51–3.33)*
0.50–0.74 85 347 1.18 (0.49–2.85)*
0.75–0.99 68 236 1.40 (0.73–2.68)
⩾1.00 95 355 1.24 (0.67–2.29)
P for linear trend     0.78
       
Fruits and vegetables high in vitamin C      
<0.5 57 317 1.00
0.5–0.9 77 376 1.10 (0.77–1.55)
1.0–1.4 96 378 1.33 (0.94–1.87)
1.5–1.9 92 280 1.54 (1.06–2.22)
⩾2.0 92 297 1.43 (0.99–2.07)
P for linear trend     0.01
       
Orange juiced      
Never 39 228 1.00
1–3 month−1 70 364 1.09 (0.73–1.62)
1 week−1 44 197 1.31 (0.83–2.05)
2–6 week−1 203 799 1.44 (1.00–2.08)
⩾1 day−1 147 499 1.61 (0.92–2.84)
P for linear trend     0.008
*

P<0.05 in test for heterogeneity of results from the NHS and NHS II.

a

Results from NHS (1984–1998) and NHS II (1991–1999) were pooled to obtain risk estimates for the combined cohorts.

b

Relative risks were adjusted for the covariates listed in Table 2 footnote c plus total energy intake, multivitamin use, and use of vitamin C, vitamin E, and β-carotene supplements.

c

95% confidence interval.

d

Follow-up for NHS is 1980 – 1998.