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. 2003 Jun 10;88(12):1948–1955. doi: 10.1038/sj.bjc.6600981

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Copyright © 2003 Cancer Research UK

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Vitamin E analogues induce apoptosis and activate caspase-3. Jurkat cells were exposed for the time shown to 50 μM each of α-TOS, α-TOM, α-TO2MS, α-TOG, α-TO3MG, γ-T3H, γ-T3S, or γ-T2H, and assessed for apoptosis extent (A) and caspase-3 activation using the antibody specific for activated caspase-3 and a secondary, FITC-conjugated antibody (B). The inset in (B) shows a typical histogram of flow cytometric evaluation of control cell and cells treated with 50 μM α-TOS for 12 h.