Table 3. Change in FACT scales with change in haemoglobin concentration (QW, Q2W, and Q3W schedules combined).
|
Haemoglobin change category (baseline to end of treatment period) |
||||
|---|---|---|---|---|
| Baseline value | 0 g dl−1 | 0 g/dL–2 g dl−1 | ⩾ 2g dl−1 | |
| FACT scales | n, Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) |
| n | 183a | 22 | 76b | 85c |
| FACT Fatigue subscale | 26.9 (25.0, 28.8) | −0.6 (−6.0, 4.8) | 1.7 (−1.1, 4.5) | 8.5 (5.9, 11.1) |
| FACT Anaemia symptoms subscale | 17.8 (17.0, 18.5) | −1.4 (−4.3, 1.5) | 0.8 (0.0, 1.6) | 2.5 (1.5, 3.5) |
| FACT Anaemia subscale scored | 44.6 (42.2, 47.1) | −2.0 (−9.7, 5.7) | 2.5 (−0.8, 5.9) | 11.0 (7.8, 14.2) |
| FACT-G Physical well-being subscale | 19.3 (18.4, 20.1) | −1.2 (−3.5, 1.1) | 0.4 (−0.9, 1.6) | 2.8 (1.6, 4.0) |
| FACT-G Social/Family well-being subscale | 21.6 (20.7, 22.5) | −0.4 (−2.9, 2.0) | −0.2 (−1.6, 1.1) | −0.4 (−1.4, 0.6) |
| FACT-G Emotional well-being subscale | 17.5 (16.8, 18.3) | −0.2 (−2.3, 2.0) | 0.8 (−0.1, 1.7) | 1.5 (0.7, 2.3) |
| FACT-G Functional well-being subscale | 14.6 (13.6, 15.6) | −2.1 (−4.6, 0.4) | 0.0 (−1.3, 1.3) | 3.6 (2.4, 4.9) |
| FACT-G Overall scalee | 73.0 (70.4, 75.6) | −3.9 (−9.7, 2.0) | 1.2 (−1.9, 4.3) | 7.6 (4.6, 10.6) |
| FACT Anaemia total scalef | 117.5 (112.7, 122.2) | −5.9 (−18.6, 6.9) | 4.1 (−1.6, 9.8) | 18.7 (12.9, 24.6) |
a
n=182 for the FACT-G Functional scale, 179 for the Social/Family scale, and 178 for the Overall and Anaemia Total scales.
b
n=73 for the FACT-G Social/Family, Overall, and Anaemia Total scales.
c
n=84 for the FACT-G Social/Family and Functional scales and 83 for the Overall and Anaemia total scales.
d
Anaemia subscale score=Fatigue+Anaemia symptoms.
e
FACT-G Overall score=Physical well-being+Social/family well-being+Emotional well-being+Functional well-being.
f
FACT Anaemia total score=FACT-G+Anaemia subscale score.