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Schematic showing the pathway for synthesis and mode of action of prostacyclin (PGI2). Various agents used in this study are also shown in the figure. COX, cyclo-oxygenase; AA, arachidonic acid; PGH2, prostaglandin H2; PGIS, prostacyclin synthase; IP, prostacyclin receptor; PDE3, phosphodiesterase 3.
