Figure 1. Structure of the SRPK1:ASF/SF2 Complex.
SRPK1 lacking the insert domain (gray) is shown bound with a truncated form of ASF/SF2 [ASF(105-219)] (gold). Density for RRM2 and a short piece of the RS domain (N′-RS1) are visible. Residues 211-219 and the PRSP sequence linking RRM2 and N′-RS1 are disordered (dotted gold line). Active site is designated by AMPPNP.