Skip to main content
. Author manuscript; available in PMC: 2010 Jul 24.
Published in final edited form as: J Mol Biol. 2009 May 27;390(4):618–634. doi: 10.1016/j.jmb.2009.05.060

Figure 9. Proposed mechanism for regiospecific phosphorylation control.

Figure 9

SRPK1 forms a high affinity complex with ASF/SF2 and starts the phosphorylates cycle in the “initiation box” at the C-terminal end of RS1 (I). Approximately seven serines are modified in the extension phase before the stability of the enzyme-substrate complex diminishes and SRPK1 can dissociate and re-bind to modify the remaining serines in RS1 or begin to modify serines in RS2.