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. 2008 Nov 19;28(47):12510–12522. doi: 10.1523/JNEUROSCI.4329-08.2008

Figure 7.

Figure 7.

Embryos injected with Scn1bbMO have reduced Na+ current amplitudes in RB neurons and display touch insensitivity. A, Peak Na+ current in RB neurons average −1329.5 ± 518.7 pA in embryos injected with Scn1bbCTL (n = 4), but only −477.2 ± 474.7 in embryos injected with Scn1bbMO (n = 5; p < 0.05; Student's t test). B, At 48 hpf, embryos injected with Scn1bbMO had an average response to touch of 4.6 ± 2.3 (n = 180), compared with an average response of 6.5 ± 2.4 (n = 180) in embryos injected with Scn1bbCTL (p < 0.001; ANOVA). Similarly, 72 hpf embryos injected with Scn1bb had an average response to touch of 5.1 ± 1.9 (n = 163) compared with an average response of 8.3 ± 1.5 (n = 60) in embryos injected with Scn1bbCTL (p < 0.001; ANOVA).