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. 2008 Nov 19;28(47):12510–12522. doi: 10.1523/JNEUROSCI.4329-08.2008

Figure 8.

Figure 8.

Scn1bbMO leads to abnormal development of motor axons, the olfactory nerve, and hair cells. A, B, Lateral views of live 72 hpf Tg(Hb9:GFP) embryos injected with Scn1bbCTL (A) or Scn1bbMO (B); anterior is to the left, and dorsal is at the top. Scale bar, 100 μm. C, D, Abnormal fasciculation of the olfactory nerve (stars) within the olfactory pit (outlined in white) in 72 hpf embryos injected with Scn1bbMO (D) versus Scn1bbCTL (C). The olfactory nerve is visualized with an immunostain against α-acetylated tubulin (red). Scale bar, 50 μm. E, F, Hair cells within the otic vesicle (outlined in white) of 72 hpf embryos injected with Scn1bbCTL (E) or Scn1bbMO (F) visualized with phalloidin (green) and α acetylated tubulin (red). Scale bar, 50 μm.