Table 4.
Tumor response and acneiform rash severity by maximum dose
| Dose | Number of patients | Responses at each dose and grade |
|---|---|---|
| 22a | ||
| 250 mg/m2 rash | ||
| Grade 0,1 | 8 | 1SDb, 7PDc |
| Grade 2 | 5 | 2 SD, 3PD |
| Grade 3 | 1 | 1PD |
| 325 mg/m2 rash | ||
| Grade 0,1 | 1 | 1SD |
| Grade 2 | 3 | 2SD, 1UDd |
| Grade 3 | 0 | |
| 400 mg/m2 rash | ||
| Grade 0,1 | 1 | 1SD |
| Grade 2 | 2 | 2SD |
| Grade 3 | 1 | 1PRe |
a
3 patients received only the loading dose (1 due to rapid progression; 1 due to severe hypersensitivity reaction; 1 due to reclassification of original histology.
b
SD = stable disease.
c
PD = progressive disease.
d
UD = undeterminable.
e
PR = partial remission.