Table 1.
Summary of the parameters used to simulate each study and the calculated maximum concentration (Cmax) and area under the curve (AUC) averaged for the cochlear locations corresponding to the frequencies tested. Injections separated by 3 or more days were regarded as a separate treatment, with the same Cmax but adding to the AUC as a multiple of the number of times the treatment cycle was performed. AUC values given are for a single treatment cycle.
| Letter | Authors | Applied Concentration (mg/ml) |
Applied Volume (μl) |
Application Duration ( min) |
Injection Protocol |
Number of Injections per Treatment |
Number of Treatment Cycles |
Audiometric Frequencies Tested (kHz) |
Cmax (μg/ml) |
Cmax (% of conc. applied) |
AUC for a single treatment cycle (mg·min/ml) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A | Nedzelski et al. (1993) | 26.7 | 1000 | 30 | 3 per day for 4 days | 12 | 1–2 | 0.5, 1, 2, 3 | 105 | 0.39 | 641 |
| B | Driscoll et al. (1997) | 40 | 250–2000 | 40 | 1 per 14 days | 1 | 1–3 | 0.5, 1, 2, 3 | 38 | 0.10 | 106 |
| C | Hirsch & Kamerer (1997) | 30 | 400 | 20 | 1 per 3 days | 1 | 1–9 | 0.5, 1, 2, 3 | 15 | 0.05 | 34 |
| D | Murofushi et al. (1997) | 30 | 750 | 60 | 1 per day for 2–5 days | 2–5 | 1–2 | 1 | 47–66 | 0.16–0.22 | 189–277 |
| E | Rauch & Oas (1997) | 40 | 500 | 60 | 1 or 2 per day | 2–7 | 1–8 | 0.5, 1, 2 | 68–130 | 0.17–0.33 | 245–3167 |
| F | McFeely et al. (1998) | 26.7 | 1000 | 30 | 3 per day for 4 days | 12 | 1 | 0.5, 1, 2, 3 | 111 | 0.42 | 424 |
| G | Pfleiderer (1998) | 26 | 650 | 30 | 3 per day for 4 days | 12 | 1–3 | 0.5, 1, 2, 4 | 108 | 0.42 | 413 |
| H | Youssef & Poe (1998) | 30 | 1000 | 45 | 1 per 7 days | 1 | 1–8 | 0.5, 1, 2, 4 | 37 | 0.12 | 94 |
| I | Minor (1999) | 26.7 | 450 | 30 | 1 per 7 days | 1 | 1–6 | 0.5, 1, 2, 3 | 19 | 0.07 | 53 |
| J | Quaranta et al. (1999) | 80 | 500 | 20 | 1 per 6 days | 1 | 2–3 | 0.5, 1, 2, 3 | 40 | 0.05 | 215 |
| K | Silverstein et al. (1999) | 26.7 | 250 | 30 | 1 per 5 days | 1 | 1–2 | 0.5, 1, 2, 3 | 19–20 | 0.07–0.08 | 52–90 |
| L | Kaplan et al. (2000) | 26.7 | 750 | 30 | 3 per day for 4 days | 12 | 1 | 0.5, 1, 2, 3 | 105 | 0.39 | 641 |
| M | Quaranta et al. (2001) | 20 | 400 | 20 | 1 per 7 days | 1 | 2–4 | 0.5, 1, 2, 3 | 10 | 0.05 | 28 |
| N | Schoendorf et al. (2001) | 40 | - | 2160–25920 | 1.5–18 days | 1 | 1 | 0.5, 1, 2, 3 | 1401–2237 | 3.50–5.59 | 5224–58484 |
| O | Abou-Halawa & Poe (2002) | 30–40 | 1000 | 45 | 1 per 7 days | 1 | 1–8 | 0.5, 1, 2, 3 | 32–48 | 0.11–0.12 | 88–117 |
| P | Wu and Minor (2003) | 26.7 | 400 | 30 | 1 per 7 days | 1 | 1–7 | 0.5, 1, 2, 3 | 19 | 0.07 | 53 |
| Q | Suryanarayanan & Cook (2004) | 10 | - | 14400 | 10 days | 1 | 1 | 0.5, 1, 2, 4 | 559 | 5.59 | 8192 |
| R | Takai et al. (2006) | 30 | 700 | 60 | 1 per 5 days | 5 | 1 | 0.5, 1, 2, 4 | 97 | 0.32 | 622 |
| S | De Beer et al. (2007) | 30 | 750 | 45 | 1 per 30 days | 1 | 1–10 | 0.5, 1, 2, 4 | 36 | 0.12 | 86 |