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. Author manuscript; available in PMC: 2009 Sep 10.
Published in final edited form as: FEBS Lett. 2008 Nov 19;582(29):4107–4111. doi: 10.1016/j.febslet.2008.11.008

Fig. 3.

Fig. 3

The double-glycine motif and the conformational change. Close-up stereo views of the nucleotide, the double-glycine motif and the switch region in the structures of GppNHp-Rab28 (A) and GDP-3′P-Rab28 (B). The hydrogen-bonding network around the γ-phosphate of the nucleotide is broken after hydrolysis and phosphate release, resulting in destabilization of the double-glycine motif and the conformational change in the switch region. Colors are according to figures 1A and 2A.