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. 2009 Jun 1;84(1):119–126. doi: 10.1093/cvr/cvp180

Figure 2.

Figure 2

Effect of LXRα deficiency on pressure overload-induce cardiac hypertrophy. Pressure overload-induced cardiac hypertrophy was exacerbated in LXRα KO mice compared with that of WT mice. Wild-type mice (C57/B6) and LXRα KO mice at their ages of 4-month-old were used for 2 weeks of TAC procedures. Age- and sex-matched sham-operated mice were served as control. (A) Ratio of heart weight to tibial length in LXRα KO and wild-type mice after 2 weeks of TAC or sham procedures. Data are expressed as mean ± SEM (n = 12, *P < 0.05 vs. sham, #P < 0.05 vs. WT). (B) Real-time PCR analyses on transcript levels of ANF in RNA samples extracted from mouse hearts after 2 weeks of TAC and sham operations. Data are expressed as mean ± SEM (n = 6, *P < 0.05 vs. sham; #P < 0.05 vs. WT).