Figure 7.

Effect of overexpression of constitutively active LXR on NF-κB activity. Cultured H₉C₂ myocytes were transfected with a pNF-κB reporter/luciferase vector and co-transfected with a control vector. Cells were transfected with ad-VP16-LXRα, ad-VP16-LXRβ, or ad-LacZ. NF-κB activities induced by (A) AngII (1 µmol/L) and (B) LPS (10 ng/mL) in the above treated cells were measured. Relative quantitation of luciferase activities represents activities of NF-κB. Data are expressed as mean ± SEM (n = 6, *P < 0.05 vs. no AngII or no LPS, ^#P < 0.05 vs. Ad-LacZ + AngII or Ad-LacZ + LPS).