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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Neurobiol Dis. 2008 Nov 5;33(2):229–235. doi: 10.1016/j.nbd.2008.10.006

Fig. 1.

Fig. 1

Age-dependent impairments of basal synaptic transmission in hippocampal slices from 5XFAD mice. A and B, Input/output (I/O) curves relating the amplitude of the presynaptic fiber volley to the slope of fEPSP at various stimulus intensities (20–100 μA) in the CA1 region of 5XFAD mice at <4 months (A) and 6 months (B) of ages. C, The summary bar graph shows significant reductions in basal synaptic transmission as measured by the average slope of I/O curves in 5XFAD mice at 6 months of age but not at <4 months of age (n = 9–11 mice per group). * P<0.05 versus wild-type controls. All data are presented as mean ± SEM.

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