Fig. 6.
Impairments of remote memory stabilization following contextual fear conditioning in 5XFAD mice at 6 months of age. A, 5XFAD mice show levels of contextual freezing equivalent to those of wild-type mice when tested 1 day after training with three CS-US pairings (n = 15–17 mice per group). B, 5XFAD mice show significantly lower levels of freezing than wild-type mice when tested 30 day after training with three CS-US pairings (n = 13 mice per group). C, 5XFAD mice show significantly lower levels of freezing than wild-type mice when tested 30 day after training with five CS-US pairings (n = 14 mice per group). * P<0.05 versus wild-type controls. All data are presented as mean ± SEM.