Table 2.

Variables associated with CKD stage 3 and/or macroalbuminuria in any time-point after islet transplant

	CKD stage 3 OR (95% CI)	P	Macroalbuminuria OR (95% CI)	P
Age (each 10 years)	2.18 (1.19 – 3.98)	0.011	1.20 (0.59 – 2.45)	0.617
Diabetes duration (years)	1.04 (0.99 – 1.09)	0.088	1.03 (0.98 – 1.08)	0.222
Gender (male)	0.44 (0.09 – 2.24)	0.324	0.30 (0.04 – 2.10)	0.225
BMI (kg/m2)	1.00 (0.93 – 1.08)	0.982	1.28 (1.00 – 1.64)	0.046
Systolic BP ≥ 130 mmHg	1.74 (0.83 – 3.65)	0.144	1.37 (0.31 – 6. 08)	0.679
Diastolic BP ≥ 80 mmHg	0.82 (0.50 – 1.34)	0.437	0.63 (0.17 – 2.28)	0.477
A1c ≥6%	0.76 (0.46 – 1.26)	0.294	0.51 (0.14 – 1.86)	0.304
LDL-cholesterol ≥ 100 mg/dl	0.91 (0.66 – 1.24)	0.546	2.63 (1.11 – 6.25)	0.028
Low HDL cholesterol a	0.96 (0.40 – 2.32)	0.936	0.70 (0.22 – 2.17)	0.535
Triglycerides >150 mg/dl	1.52 (0.96 – 2.45)	0.073	0.24 (0.04 – 1.69)	0.153
CKD stage 1 or 2 b	0.22 (0.05 – 0.97)	0.050	0.70 (0.12 – 3.94)	0.681
Microalbuminuria b	13.12 (3.53 – 48.80)	<0.001	5.44 (1.58 – 18.70)	0.007
ACEi	2.45 (0.98 – 6.14)	0.056	2.38 (0.58 – 9.82)	0.231
ARB	2.80 (0.99 – 7.94)	0.052	3.00 (0.79 – 11.40)	0.107
Statins	1.76 (0.96 – 3.21)	0.067	3.25 (0.90 – 11.75)	0.071
3 or 4 islets transplants	2.2 (0.83 – 6.24)	0.110	3.87 (0.99 – 15.12)	0.051
Tacrolimus	0.69 (0.43 – 1.09)	0.111	0.20 (0.09 – 0.41)	<0.001
Sirolimus	1.13 (0.61 – 2.11)	0.704	3.09 (0.37 – 24.35)	0.289

Data expressed as odds ratio (OR) and 95% confidential interval (CI). CKD = chronic kidney disease based on National Kidney Foundation (NKF) guidelines, BMI = body mass index, BP = blood pressure, ACEi = angiotensin-converting enzyme inhibitors, ARB = angiotensin receptor blockers.

^aHDL cholesterol <40 mg/dl for males or <50 mg/dl for females

^bbased on pre-transplant classification.