Table 2.

Mean estimate and changes in HRQoL according to different variables analyzed.

	DQoL			HSQ 2.0
	Satisfaction	Impact	Worry	Health perception	Physical function	Role-limit phys health	Role-limit emotion	Social function	Mental health	Body pain	Energy
DM Duration	NS	−0.2±0.1a	NS	NS	NS	NS	NS	NS	NS	NS	NS
Protocol
IA	NS	NS	NS	69±3b, c	95±2	NS	96±2b	NS	NS	NS	71±4
IAK				55±6b	88±5 b		97±3				62±4b
IBM				101±5	104±4		103±3				84±7
Insulin dosage	NS	−14.1±5a	NS	NS	NS	NS	NS	NS	NS	NS	NS
A1C	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Infusion No.
1	NS	NS	NS	66±3d	NS	NS	94±3e	87±3e	NS	NS	68±4e
2				83±4			99±2	92±3			72±4
3				76±7			103±2	98±4			77±5
Recent period	NS	NS	4.1±2a	NS	NS	NS	NS	NS	NS	NS	NS
after infusion
NCI I-II	NS	−3.6±1a	NS	−6.3±3a	NS	NS	NS	NS	−4.4±2a	NS	−5.9±3a
NCI III-IV	−5.7±2a	NS	−5.2±2a	−9.9±3a	−3.9±2a	NS	−3.6±2a	−6.4±2a	NS	NS	−9.3±3a
Exnenatide	NS	NS	NS	9.5±3a	NS	NS	NS	NS	3.7±2a	NS	NS

Results are expressed as mean estimate±SEM for nominal variables (protocol and infusion number). For ordinal variables (recent period after infusion, NCI I-II, NCI III-IV and exenatide usage), results are score changes based on exposure. For continuous variables, data are score changes based on one unit increment (each increasing year for diabetes duration and each 1 IU/kg/day for insulin dosage).

HRQoL=Health related quality of life, DQoL=Diabetes Quality of Life, HSQ=Health Status Questionnaire, role-limit phys health=role-limitation physical health, role-limit emotion=role-limitation emotion, DM=Diabetes mellitus, IA=Islet transplant alone, IAK=Islet after kidney transplantation, IBM=Islet with bone marrow transplantation, NCI=Common terminology criteria for adverse events (National Cancer Institute), NS=non-significant

^ap<0.05

^bcomparing with IBM; p<0.05

^ccomparing with IAK; p<0.05

^dcomparing with 2 infusions; p<0.05

^ecomparing with 3 infusions; p<0.05.