TABLE 1.
Prandial food and water intake and meal microstructure during a representative 24-h period of basal ingestive behavior of CRF2 wild-type (WT) and knockout (KO) mice
| Dark phase | Light phase | |||
|---|---|---|---|---|
| WT | KO | WT | KO | |
| Food and water | ||||
| No. of meals*** | 15.9 ± 1.1 | 17.3 ± 1.2 | 10.1 ± 0.6 | 8.4 ± 0.6 |
| Meal size (pellets and units of water / meal)* |
11.4 ± 0.9 | 12.3 ± 0.7 | 10.2 ± 0.7 | 10.5 ± 0.8 |
| Meal duration (min)* | 7.3 ± 0.8 | 7.6 ± 0.7 | 9.6 ± 1.4 | 9.3 ± 0.8 |
| Intermeal interval (min)*** | 37.6 ± 2.5 | 36.5 ± 3.3 | 67.6 ± 5.6 | 86.3 ± 6.8 |
| Water : food ratio* | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 |
| Meal rate of intake (pellets and units of water / min)*** |
1.8 ± 0.2 | 1.9 ± 0.1 | 1.5 ± 0.2 | 1.6 ± 0.1 |
| Food | ||||
| Food intake (g) | 2.5 ± 0.1 | 3.0 ± 0.1† | 1.5 ± 0.1 | 1.3 ± 0.1 |
| Meal size (pellets / meal) | 8.1 ± 0.6 | 8.8 ± 0.4 | 7.3 ± 0.5 | 8.1 ± 0.4 |
| Meal duration (min)* | 4.2 ± 0.3 | 4.1 ± 0.2 | 5.1 ± 0.6 | 5.0 ± 0.5 |
| Eating rate (pellets / min)** | 2.1 ± 0.2 | 2.3 ± 0.1 | 1.9 ± 0.2 | 2.0 ± 0.1 |
| Satiety ratio (min / g food eaten)*** |
280 ± 23 | 226 ± 17 | 616 ± 79 | 693 ± 88 |
| Water | ||||
| Water intake (ml) | 1.9 ± 0.2 | 2.3 ± 0.3 | 1.1 ± 0.2 | 0.9 ± 0.2 |
| Meal size (units of water / meal) |
3.3 ± 0.3 | 3.5 ± 0.3 | 2.8 ± 0.3 | 2.6 ± 0.5 |
| Meal duration (min) | 1.7 ± 0.3 | 1.8 ± 0.4 | 1.8 ± 0.5 | 1.8 ± 0.5 |
Values are means ± SEM for selected meal-related parameters. Genotype was a between-subject factor and time (dark vs. light phase) was a within-subject factor.
***
Significant time effect P < 0.0001
**
P < 0.01
*
P < 0.05
†
Significant main genotype × time interaction (P < 0.05).
CRF, corticotropin-releasing factor.