. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Bone. 2009 Jun 25;45(4):716–725. doi: 10.1016/j.bone.2009.06.020

Table 1.

Gene Ontology (GO) sub-categories significantly influenced by PTH according to the mode of exposure.

	Biological process (GO:8150)

Treatment	Development (GO:7275)	Physiological process (GO:7582)	Growth (GO:40007)	Response to stimulus (GO:50896)
i.PTH	-regulation of cell size ^c	-immune response ^c	-cell growth ^c	-response to chemical stimuli ^c
	-vascular development ^c	-ossification ^a		-defense response ^c
	-skeletal development ^b	-bone remodeling ^a		-response to external stimuli ^c

i.PTH & c.PTH	-glial cell differentiation ^b	-copper ion transport ^c		-defense response ^a
	-segmentation ^a	-death ^a
		-thyroid hormone catabolism ^a

c.PTH		-copper ion transport ^b		-response to wounding ^a
		-inflammatory response ^a		-response to external stimuli ^a
		-cytosolic calciumion homeostasis ^a		-chemotaxis ^a

The list of sequences regulated uniquely by i.PTH, c.PTH or both in WT osteoblast cultures was subjected to Gene Ontology analysis. The mentioned categories are the most significant and relevant with regard to bone biology.

p<0.05

p<0.001

p<0.0001.