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Microglia NADPH oxidase is the target of TGFβ1 inhibition in LPS-induced neurotoxicity. PHOX+/+ and PHOX–/– mice neuron-glia cultures were pretreated with vehicle or TGFβ1 for 1 h followed by LPS treatment. Neurotoxicity was assessed by DA uptake. Results are expressed as % of the control culture, and are the means ± SE of 3 individual experiments in triplicate in each experiment. **P < 0.01 compared with LPS treated culture.
