Figure 8.

Mutations in rolled suppress the unc-51 defect in evoked transmitter release. A, B, Representative spontaneous mEJPs (A) and EJPs (B) are shown from the same genotypes as in Figure 5. C, D, Histograms show the mean EJP amplitude (C) and quantal content (D) from WT (CS crossed to w⁻), unc-51³ deletion mutant, homozygous rl¹ hypomorphs, and rl¹+unc-51³ (rl¹; unc-51³). ***p < 0.001; n = 10 for all genotypes; and error bars represent SEM. p < 0.001 when either unc-51³ or rl¹ is compared with either wild type or double mutant. There is no significant difference between WT and double mutant (p = 0.3). Calibration: mEJP, 2.5 mV, 100 ms; EJP, 5 mV, 5 ms.